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 Immunomodulatory effects of dietary whey proteins in mice

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Hei865
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Number of posts : 11
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Grade (Ex:IET04 or guest) : CM04
Registration date : 2006-09-07

PostSubject: Immunomodulatory effects of dietary whey proteins in mice   Tue Oct 17, 2006 12:35 am

By CHUN W. WONG AND DENNIS L. WATSON
CSIRO Division of Animal Health, Armidale, NSW 2350, Australia

SUMMARY. Studies on the immunomodulatory properties of dietary whey proteins in mice are reported. Ingestion of bovine milk whey proteins, either as a supplement in an adequately balanced commercial diet or as the only protein source in a balanced diet, consistently enhanced secondary humoral antibody responses following systemic immunization with ovalbumin, when compared with other protein sources such as soyabean protein isolate and ovine colostral whey proteins. After 5-8 weeks of feeding, dietary milk whey proteins enhanced cell-mediated immune responses as revealed by footpad delayed type hyper-sensitivity responses, and coneanavalin A-induced spleen cell proliferative responses. To monitor nutritional effects of milk whey proteins, live weight, leucocyte counts and clinical changes of diet-fed mice were examined. The present results confirm other previous results that dietary bovine milk whey proteins have immunoenhancing properties in mice and these properties are unlikely to be related solely to the nutritional effects.
Whey contains a multitude of proteins that remain soluble after precipitation of caseins during the manufacture of cheese (Eigel et al. 1984). There are major components such as -lactoglobulin, a-lactalbumin, serum albumin and immuno-globulins, and minor components such as lactoferrin, lactoperoxidase (EC 1. 11. 1.7) and various growth factors. Many of these components possess immunobiological properties (Ogra & Ogra, 1978; Juto, 1985; Stoeck et al. 1989; Mincheva-Nilsson et al. 1990; Watson. 1990; Barta et al. 1991). It is evident that peptides and the amino acids incorperated in them can influence the immune response in different ways, and minor changes in the dietary amino acid profile may modulate the immune response without significant impact on nutritional status (Belokrylov et al. 1992). Therefore, it is possible that, unique amino acid groups or peptides derived from whey proteins after ingestion may have significant immunomodulatory activities in vivo.
Recent evidence suggests that a diet based on whey protein could enhance the IgM plaque-forming cell response in mouse spleen and prevent colon tumour growth in mice when compared with diets containing other protein sources (Bounous et al. 1988a, b). The prophylactic potential of whey proteins against initiation of colon tumours was further supported by a more recent study using a rat model (McIntosh, 1993). In addition, results from a preliminary clinical trial led Bounous et al. (1993) to propose that dietary whey proteins may have beneficial effects in human immunodeficiency virus (HIV)-infected patients. In view of these recent studies, a better understanding of the immunological properties of whey proteins and their underlying mechanisms would be of value in assessing their potential clinical or pharmaceutical applications. In the present study we have investigated the effects of dietary bovine milk whey protein concentrate on both humoral and cell-mediated immune responses in mice.
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Hung
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Number of posts : 3
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Registration date : 2006-09-18

PostSubject: Re: Immunomodulatory effects of dietary whey proteins in mice   Tue Oct 17, 2006 1:20 am

You should be a prof instead of a student, Henry lol! Bravo my roomate !!! cheers Laughing
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